FluPhenotype One-stop platform for early warnings of influenza A viruses
The vaccine or reference strains used in this web server are listed as follows:
| HA subtype | Vaccine or reference strain | GenBank or GISAID accession number |
The mammalian virulence related molecular markers are listed as follows:
| Protein Type | Amino acid site | Phenotypic consequences | Reference |
The human-adaptation associated amino acid markers are as follows:
| Protein Type | Human residues |
Avian residues |
Reference |
The antiviral drug related molecular markers are listed as follows:
| Protein Type | Amino acid site (Oseltamivir) |
Amino acid site (Zanamivir) |
Reference |
| Protein Type | Amino acid site (Amantadine) |
Reference |
| Protein Type | Amino acid site (baloxavir marboxil, EC50 fold) |
Reference |
| PA | 23G | PMID:30670144 |
| 23K | PMID:30670144 | |
| 36V | PMID:30670144 | |
| 37T | PMID:30670144 | |
| 38T | PMID:30771405 | |
| 38M | PMID:30771405 | |
| 38F | PMID:30771405 | |
| 38L | PMID:30670144 | |
| 119D | PMID:30670144 | |
| 199G | PMID:30670144 |
| Resistance with unknown IC50 | |
| Low level of resistance（2<IC50 fold-change≤10） | |
| Middle level of resistance（10<IC50 fold-change≤100） | |
| High levels of resistance（100<IC50 fold-change） |