A database of 305 pairs of mammalian virus-host receptor interaction, which included 138 unique viral species/sub-species and 143 receptors, are curating by Peng Lab. We analyzed the structural, functional, evolutionary and tissue-specific expression characteristics of mammalian virus receptors, and provide some new insights into viral receptor selection and identify viral receptors (see more details).

Family Family TaxID Virus Virus TaxID Host Host TaxID UniprotKB AC Refseq protein Gene name Gene GeneID Pubmed
Herpesviridae 10292 Human alphaherpesvirus 1 10298 Homo sapiens (Human) 9606P06756 NP_001138471.1integrin subunit alpha VITGAV3685 PMID: 24367260   
Herpesviridae 10292 Human alphaherpesvirus 1 10298 Homo sapiens (Human) 9606P18564NP_000879.2integrin subunit beta 6ITGB63694 PMID: 24367260   
Herpesviridae 10292 Human alphaherpesvirus 1 10298 Homo sapiens (Human) 9606P26012 NP_002205.1integrin subunit beta 8ITGB83696 PMID: 24367260   
Herpesviridae 10292 Human alphaherpesvirus 1 10298 Homo sapiens (Human) 9606Q15223NP_002846.3nectin cell adhesion molecule 1NECTIN15818 PMID: 9657005 9616127   
Herpesviridae 10292 Human alphaherpesvirus 1 10298 Homo sapiens (Human) 9606Q92692 NP_001036189.1nectin cell adhesion molecule 2NECTIN25819 PMID: 9657005   
Herpesviridae 10292 Human alphaherpesvirus 1 10298 Homo sapiens (Human) 9606Q92956NP_003811.2TNF receptor superfamily member 14TNFRSF148764 PMID: 9696799 11511370   
Herpesviridae 10292 Human alphaherpesvirus 1 10298 Homo sapiens (Human) 9606Q9NNX6 NP_001138365.1CD209 moleculeCD20930835 PMID: 18796707   
Herpesviridae 10292 Human alphaherpesvirus 1 10298 Sus scrofa (Pig) 9823Q9GL76NP_001001262.1nectin cell adhesion molecule 1NECTIN1397247 PMID: 22955284   
Herpesviridae 10292 Human alphaherpesvirus 1 10298 Mus musculus (Mouse) 10090Q9JKF6 NP_067399.2nectin cell adhesion molecule 1Nectin158235 PMID: 22955284   
Herpesviridae 10292 Human alphaherpesvirus 2 10310 Homo sapiens (Human) 9606Q15223NP_002846.3nectin cell adhesion molecule 1NECTIN15818 PMID: 9657005 9616127   
Herpesviridae 10292 Human alphaherpesvirus 2 10310 Homo sapiens (Human) 9606Q92692 NP_001036189.1nectin cell adhesion molecule 2NECTIN25819 PMID: 11602758 9657005   
Herpesviridae 10292 Human alphaherpesvirus 2 10310 Homo sapiens (Human) 9606Q92956NP_003811.2TNF receptor superfamily member 14TNFRSF148764 PMID: 9696799 11511370   
Herpesviridae 10292 Human alphaherpesvirus 2 10310 Homo sapiens (Human) 9606Q9NNX6 NP_001138365.1CD209 moleculeCD20930835 PMID: 18796707   
Herpesviridae 10292 Human alphaherpesvirus 2 10310 Sus scrofa (Pig) 9823Q9GL76NP_001001262.1nectin cell adhesion molecule 1NECTIN1397247 PMID: 22955284   
Herpesviridae 10292 Human alphaherpesvirus 2 10310 Mus musculus (Mouse) 10090Q9JKF6 NP_067399.2nectin cell adhesion molecule 1Nectin158235 PMID: 22955284 9616127   
Herpesviridae 10292 Bovine alphaherpesvirus 1 10320 Homo sapiens (Human) 9606P15151NP_001129240.1poliovirus receptorPVR5817 PMID: 9616127   
Herpesviridae 10292 Bovine alphaherpesvirus 1 10320 Homo sapiens (Human) 9606Q15223 NP_002846.3nectin cell adhesion molecule 1NECTIN15818 PMID: 9616127   
Herpesviridae 10292 Equid alphaherpesvirus 1 10326 Equus caballus (Horse) 9796F6UR46NOintegrin subunit beta 1ITGB1100055024 PMID: 23514881   
Herpesviridae 10292 Equid alphaherpesvirus 1 10326 Equus caballus (Horse) 9796F6ZZX8 NOintegrin subunit alpha 4ITGA4100067886 PMID: 23514881   
Herpesviridae 10292 Equid alphaherpesvirus 1 10326 Equus caballus (Horse) 9796Q30488NP_001093236.1MHC class I heavy chainMHCX1100056391 PMID: 20610718   
Herpesviridae 10292 Equid alphaherpesvirus 4 10331 Equus caballus (Horse) 9796Q30488 NP_001093236.1MHC class I heavy chainMHCX1100056391 PMID: 24722677   
Herpesviridae 10292 Human alphaherpesvirus 3 10335 Homo sapiens (Human) 9606P14735NP_001159418.1insulin degrading enzymeIDE3416 PMID: 17055432 17553876   
Herpesviridae 10292 Suid alphaherpesvirus 1 10345 Homo sapiens (Human) 9606P15151 NP_001129240.1poliovirus receptorPVR5817 PMID: 9616127   
Herpesviridae 10292 Suid alphaherpesvirus 1 10345 Homo sapiens (Human) 9606Q15223NP_002846.3nectin cell adhesion molecule 1NECTIN15818 PMID: 9657005 9616127   
Herpesviridae 10292 Suid alphaherpesvirus 1 10345 Homo sapiens (Human) 9606Q92692 NP_001036189.1nectin cell adhesion molecule 2NECTIN25819 PMID: 9657005   
Herpesviridae 10292 Suid alphaherpesvirus 1 10345 Sus scrofa (Pig) 9823Q9GL76NP_001001262.1nectin cell adhesion molecule 1NECTIN1397247 PMID: 22955284   
Herpesviridae 10292 Suid alphaherpesvirus 1 10345 Mus musculus (Mouse) 10090Q9JKF6 NP_067399.2nectin cell adhesion molecule 1Nectin158235 PMID: 22955284   
Herpesviridae 10292 Human betaherpesvirus 5 10359 Homo sapiens (Human) 9606A6ND48NP_001004734.1olfactory receptor family 14 subfamily I member 1OR14I1401994 PMID: 30894498   
Herpesviridae 10292 Human betaherpesvirus 5 10359 Homo sapiens (Human) 9606P05106 NP_000203.2integrin subunit beta 3ITGB33690 PMID: 15834425   
Herpesviridae 10292 Human betaherpesvirus 5 10359 Homo sapiens (Human) 9606P05556NP_002202.2integrin subunit beta 1ITGB13688 PMID: 20660204   
Herpesviridae 10292 Human betaherpesvirus 5 10359 Homo sapiens (Human) 9606P06756 NP_001138471.1integrin subunit alpha VITGAV3685 PMID: 15834425   
Herpesviridae 10292 Human betaherpesvirus 5 10359 Homo sapiens (Human) 9606P15144NP_001141.2alanyl aminopeptidase, membraneANPEP290 PMID: 8105105   
Herpesviridae 10292 Human betaherpesvirus 5 10359 Homo sapiens (Human) 9606Q9H2X3 NP_001138377.1C-type lectin domain family 4 member MCLEC4M10332 PMID: 12433371   
Herpesviridae 10292 Human betaherpesvirus 5 10359 Homo sapiens (Human) 9606Q9NNX6NP_001138365.1CD209 moleculeCD20930835 PMID: 12433371 22496863   
Herpesviridae 10292 Human herpesvirus 6 10368 Homo sapiens (Human) 9606P15529 NP_002380.3CD46 moleculeCD464179 PMID: 12724329 12663806   
Herpesviridae 10292 Human betaherpesvirus 7 10372 Homo sapiens (Human) 9606P01730NP_000607.1CD4 moleculeCD4920 PMID: 7909607   
Herpesviridae 10292 Human gammaherpesvirus 4 10376 Homo sapiens (Human) 9606O43921 NP_001396.2ephrin A2EFNA21943 PMID: 29292384   
Herpesviridae 10292 Human gammaherpesvirus 4 10376 Homo sapiens (Human) 9606P01911NOmajor histocompatibility complex, class II, DR beta 1HLA-DRB13123 PMID: 9151859   
Herpesviridae 10292 Human gammaherpesvirus 4 10376 Homo sapiens (Human) 9606P05556 NP_002202.2integrin subunit beta 1ITGB13688 PMID: 17945327   
Herpesviridae 10292 Human gammaherpesvirus 4 10376 Homo sapiens (Human) 9606P17927NP_000564.2complement C3b/C4b receptor 1 (Knops blood group)CR11378 PMID: 23416052   
Herpesviridae 10292 Human gammaherpesvirus 4 10376 Homo sapiens (Human) 9606P20023 NP_001006659.1complement C3d receptor 2CR21380 PMID: 22137275 17881405 2460635   
Herpesviridae 10292 Hepatitis E virus 12461 Homo sapiens (Human) 9606P26006NP_002195.1integrin subunit alpha 3ITGA33675 PMID: 31421623 31547135   
Herpesviridae 10292 Human betaherpesvirus 6A 32603 Homo sapiens (Human) 9606P15529 NP_002380.3CD46 moleculeCD464179 PMID: 23674671   
Herpesviridae 10292 Human betaherpesvirus 6B 32604 Homo sapiens (Human) 9606P43489NP_003318.1TNF receptor superfamily member 4TNFRSF47293 PMID: 23674671   
Herpesviridae 10292 Human gammaherpesvirus 8 37296 Homo sapiens (Human) 9606P05106 NP_000203.2integrin subunit beta 3ITGB33690 PMID: 18045938   
Herpesviridae 10292 Human gammaherpesvirus 8 37296 Homo sapiens (Human) 9606P06756NP_001138471.1integrin subunit alpha VITGAV3685 PMID: 18045938   
Herpesviridae 10292 Human gammaherpesvirus 8 37296 Homo sapiens (Human) 9606P52798 NP_005218.1ephrin A4EFNA41945 PMID: 30782663   
Adenoviridae 10508 Human mastadenovirus B 108098 Homo sapiens (Human) 9606P15529NP_002380.3CD46 moleculeCD464179 PMID: 14566335   
Adenoviridae 10508 Human mastadenovirus B 108098 Homo sapiens (Human) 9606P33681 NP_005182.1CD80 moleculeCD80941 PMID: 16920215   
Adenoviridae 10508 Human mastadenovirus B 108098 Homo sapiens (Human) 9606P42081NP_001193853.1CD86 moleculeCD86942 PMID: 16920215   
Adenoviridae 10508 Human mastadenovirus A 129875 Homo sapiens (Human) 9606P78310 NP_001193992.1CXADR, Ig-like cell adhesion moleculeCXADR1525 PMID: 9733828   
Adenoviridae 10508 Human mastadenovirus C 129951 Homo sapiens (Human) 9606P06756NP_001138471.1integrin subunit alpha VITGAV3685 PMID: 20615244   
Adenoviridae 10508 Human mastadenovirus C 129951 Homo sapiens (Human) 9606P18084 NP_002204.2integrin subunit beta 5ITGB53693 PMID: 20615244   
Adenoviridae 10508 Human mastadenovirus C 129951 Homo sapiens (Human) 9606P78310NP_001193992.1CXADR, Ig-like cell adhesion moleculeCXADR1525 PMID: 9733828   
Adenoviridae 10508 Human mastadenovirus E 130308 Homo sapiens (Human) 9606P78310 NP_001193992.1CXADR, Ig-like cell adhesion moleculeCXADR1525 PMID: 9036860 9733828   
Adenoviridae 10508 Human mastadenovirus F 130309 Homo sapiens (Human) 9606P78310NP_001193992.1CXADR, Ig-like cell adhesion moleculeCXADR1525 PMID: 9733828   
Adenoviridae 10508 Human mastadenovirus D 130310 Homo sapiens (Human) 9606P15529 NP_002380.3CD46 moleculeCD464179 PMID: 15047806   
Adenoviridae 10508 Human mastadenovirus D 130310 Homo sapiens (Human) 9606P78310NP_001193992.1CXADR, Ig-like cell adhesion moleculeCXADR1525 PMID: 9733828   
Papillomaviridae 151340 Human papillomavirus type 16 333760 Homo sapiens (Human) 9606P23229 NP_000201.2integrin subunit alpha 6ITGA63655 PMID: 11341777   
Papillomaviridae 151340 Human papillomavirus type 16 333760 Homo sapiens (Human) 9606P48509NP_001034579.1CD151 molecule (Raph blood group)CD151977 PMID: 23302890   
Polyomaviridae 151341 JC polyomavirus 10632 Homo sapiens (Human) 9606P28223 NP_000612.15-hydroxytryptamine receptor 2AHTR2A3356 PMID: 20660194