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African swine fever virus (ASFV) is a large and complex double-stranded DNA virus that causes serious threats to pig industry. The multigene family (MGF) proteins are extensively distributed in ASFVs, and play important roles in viral infection of hosts, including the transcription and translation, virulence, immune escape, etc. The great diversity of MGF protein brings difficulties to the research of ASFV. Therefore, the classification of MGF proteins can facilitate in-depth study of functions of MGF proteins in ASFVs.
A total of 31 MGF groups were obtained using the tool of OrthoFinder, including three groups in MGF-100 (named as MGF-100A~MGF-100C), nine groups in MGF-110 (named as MGF-110A~MGF-110G), three groups in MGF-300 (named as MGF-300A~MGF-300B), eleven groups in MGF-360 (named as MGF-360A~MGF-360M), five groups in MGF-505 (named as MGF-505A~MGF-505J).
The blastX and blastp were used to classify the MGF proteins. The MGF group of the blast best hit was taken as the group of the query protein.
Warnings: stop prediction if the query protein is not a MGF protein
Citation: Zhaozhong Zhu, Huiting Chen, Li Liu, Yang Cao, Taijiao Jiang, Yuanqiang Zou, Yousong Peng. Manuscript in preparation.